Hydroxychloroquine (Plaquenil)

What is hydroxychloroquine?

Originally developed as an anti-malarial medication, hydroxychloroquine is now more commonly used in the treatment of rheumatologic and autoimmune conditions. In the field of dermatology, it is most often prescribed for various types of lupus, and occasionally for other autoimmune conditions such as lichen planus, lichen planopilaris, and vasculitis.

What are possible side effects of hydroxychloroquine?

Hydroxychloroquine can lead to a decrease in blood counts and may cause liver inflammation. For this reason, blood tests are generally required a few weeks after starting the medication. Long-term use can result in deposits forming in the eyes, making it necessary to discontinue the medication. Regular eye examinations are important for those on long-term hydroxychloroquine therapy, and any changes in vision should be promptly reported.

How is hydroxychloroquine used?

Dosage for hydroxychloroquine is typically based on body weight and can be taken once or twice a day. The medication takes longer to show its effects, often requiring 8-12 weeks. It's crucial to allow sufficient time for the medication to take effect before considering discontinuation.

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