Isotretinoin (Accutane)
What is isotretinoin?
Isotretinoin (Accutane) is a retinoid, derived from vitamin A, used primarily for the treatment of severe acne. It is a potent medication, and the majority of people who complete a treatment cycle typically experience long-term remission from acne. Due to its potential side effects, it is generally reserved for those with significant acne who have not responded to other treatments. However, patients who take isotretinoin are closely monitored, and most do not experience severe side effects.
What are possible side effects of isotretinoin?
Isotretinoin has a range of side effects that need to be carefully considered. These fall into four main categories:
Skin dryness and sun sensitivity: Use gentle skincare products, avoid excessive sun exposure, and steer clear of procedures that could impair skin healing.
Lab abnormalities: These may include liver dysfunction or elevated triglycerides. Limit alcohol intake and maintain a balanced diet while on isotretinoin.
Risk of birth defects: For patients who can become pregnant, dual forms of birth control are mandatory. All patients must participate in the FDA-mandated iPLEDGE program.
Rare risk of mood changes: Although most people experience mood improvement due to clearer skin, there's a slight risk of worsening depression. Address depressive symptoms before starting the medication and notify your healthcare provider if you experience mood changes.
Side effects generally subside about 30 days after discontinuing the medication.
How is isotretinoin used?
Opting for isotretinoin treatment is a significant decision that requires strict adherence to the treatment protocol. This includes monthly appointments, regular lab tests, and open communication with your healthcare provider.
For more detailed guidance, consult the isotretinoin instruction sheet and isotretinoin FAQ sheet available under patient resources.