Biologics for Atopic Dermatitis

What are Biologics for Atopic Dermatitis?

Biologics for atopic dermatitis, often referred to as eczema, are advanced medications designed to treat moderate to severe instances of the condition. These medications specifically target components of the immune system that play a role in atopic dermatitis. The mode of administration is typically through injections. Currently, there are two FDA-approved biologics for this purpose: dupilumab (Dupixent) and tralokinumab (Adbry). They are primarily recommended for individuals who haven't shown a positive response to topical treatments.

How do Biologics for Atopic Dermatitis Work?

  • Targeted Immune Response: These biologics specifically target and inhibit overactive components of the immune system that are known to trigger inflammation and other symptoms of atopic dermatitis.

  • Symptom Reduction: By doing so, they help reduce the itching, redness, and inflammation commonly associated with the condition.

What are Possible Side Effects of Biologics for Atopic Dermatitis?

Patients typically undergo blood tests before commencing treatment with biologics to screen for any underlying infections. Subsequent checks might be periodically required. Common side effects associated with dupilumab include:

  • Conjunctivitis: Leading to dry or irritated eyes

  • Herpes virus infections

  • Facial rashes

While these side effects can usually be treated, a lack of improvement might necessitate a switch in medications. Other side effects, such as reactions at the injection site and more uncommon issues, should be addressed with your dermatologist for clarity and guidance.

How are Biologics for Atopic Dermatitis Used?

Administered through injections, biologics are usually taken every two weeks. Comprehensive instructions on self-administration should be provided when these medications are prescribed. A notable aspect of these biologics is that they require refrigeration. It's imperative to understand that while these are effective in symptom management, they aren't a cure. Discontinuing the medication might lead to the return of symptoms within a span of a few weeks to months. Obtaining these medications might also necessitate special insurance approval.

Precautions:

  • Proper storage is essential to ensure the effectiveness of the medication.

  • Regular monitoring and check-ups are advised to ensure the medication is working as intended and to screen for any potential side effects.

  • Always consult with your dermatologist or healthcare provider about any concerns or questions related to biologics for atopic dermatitis.

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