Methotrexate

What is methotrexate?

Methotrexate is a medication that modulates the immune system. It is commonly used in dermatology for treating conditions like eczema, psoriasis, as well as autoimmune diseases such as lupus and autoimmune blistering diseases. While dermatology generally employs low doses of this medication, higher doses are used in other medical specialties like hematology and rheumatology.

What are possible side effects of methotrexate?

Methotrexate can affect your immune system, increasing the risk of infections. If you show symptoms of an infection, it's crucial to temporarily discontinue the medication to allow your immune system to recover. Methotrexate can also impact liver and kidney functions and may lower blood cell counts. Regular blood work is required while on this medication. If you have a history of liver conditions such as hepatitis, or if you consume alcohol excessively, disclose this information before starting the medication. Side effects like fatigue and nausea are common, particularly on the day the medication is taken.

How is methotrexate used?

Methotrexate is administered orally once a week. On the remaining days, a folic acid supplement (a Vitamin B derivative) is recommended to mitigate potential side effects. Some dermatologists suggest taking the medication over the weekend to allow for rest in case of side effects.