Topical PDE4 Inhibitors

What are topical PDE4 inhibitors?

Topical PDE4 inhibitors, like crisaborole (Eucrisa), represent a relatively new advancement in the treatment of atopic dermatitis (eczema). They offer an alternative to steroids, targeting the inflammation associated with eczema by inhibiting an enzyme called phosphodiesterase-4 (PDE4). This enzyme is found in higher concentrations in individuals with eczema and is thought to contribute to inflammation when overactive.

What are possible side effects of topical PDE4 inhibitors?

While generally well-tolerated, the most common side effect of crisaborole is skin burning or stinging upon application. This does not mean you are allergic to the medication. Over time and with consistent use, these sensations typically decrease, although some people may need to switch medications. Other side effects, although less common, might include skin redness, itching, or swelling. Always discuss any persistent or concerning side effects with a dermatologist.

How are topical PDE4 inhibitors used?

These inhibitors are designed for direct application to eczema flare-ups and should be used twice daily or as directed by a dermatologist. Consistent application can lead to a noticeable reduction in the severity and frequency of flare-ups.